/* An editorial research system. This file is injected only for review captures. */
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body{background:#fff;color:var(--ink);font-size:16px}
nextjs-portal{display:none}
.container{max-width:1280px;padding-left:40px;padding-right:40px}
h1,h2,h3{color:#081831;font-family:Georgia,'Times New Roman',serif;font-weight:700;letter-spacing:-.045em}
h1{line-height:1.045}h2{line-height:1.14}p{color:inherit}
.preview-strip{background:#edf5f9;border-bottom:1px solid #d7e8f1;color:#38566c}
.preview-strip .container{min-height:30px}
.site-header{background:rgba(255,255,255,.98);box-shadow:none}
.header-inner{min-height:88px;gap:30px}
.brand{font-size:31px;letter-spacing:-1.6px;gap:12px}
.brand-symbol{width:34px;height:34px;border-width:7px}.brand-symbol:after{top:5px}
.desktop-nav{gap:26px}.desktop-nav a{font-size:13px;line-height:88px}
.header-actions{display:flex;gap:9px;align-items:center}
.header-actions [data-search-open]{width:auto;min-width:215px;gap:12px;border-radius:10px;justify-content:flex-start;padding:12px 16px;background:#f4f9fc;height:44px}
.opt-search-label{font-size:12px;color:#426077;font-weight:500;white-space:nowrap}
.eyebrow{font-size:10px;letter-spacing:.16em;color:#075783}
.button{min-height:46px;padding:11px 21px;border-radius:9px;box-shadow:none}
.button.ember{background:#f18a12;border:1px solid #d87404;color:#172237}
.button.secondary{border-color:#9fbed1}
.home-opening{position:relative;min-height:490px;margin-top:28px;padding:54px 48px 50px;border-radius:20px;overflow:hidden;display:block;border-color:#d6e8f2;box-shadow:none;background-image:linear-gradient(90deg,#f1f8fc 0%,rgba(241,248,252,.98) 38%,rgba(241,248,252,.45) 63%,rgba(241,248,252,0) 100%),url('/assets/receptor-atmosphere.png');background-size:cover;background-position:50% 55%}
.opt-home-copy{position:relative;z-index:1;max-width:585px}
.home-opening h1{font-size:57px;line-height:1.035;max-width:585px;margin-bottom:22px}
.home-opening h1 em{color:#155b80}
.home-opening .lede{font-size:17px;line-height:1.6;max-width:460px;font-weight:400;margin:0 0 27px;color:#27485f}
.opt-research-search{padding:6px;display:flex;gap:8px;background:#fff;border:1px solid #9fbed1;border-radius:11px;max-width:540px;box-shadow:0 5px 16px #214e6910}
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.opt-drug-links>span{color:#526c7f}.opt-drug-links a{font-weight:650;color:#075783;text-decoration:none;border-bottom:1px solid #a6c4d5;padding:2px 0}
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.opt-research-paths a:first-child{padding-left:3px}.opt-research-paths a:last-child{border:0}
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.opt-research-paths strong{font-size:13px;padding-right:15px}.opt-path-sub{font-size:11px;color:var(--muted)}.opt-path-arrow{position:absolute;right:17px;top:0;font-size:19px;color:#0b527c}
.home-feature{grid-template-columns:1.1fr 1fr;min-height:390px;border-radius:16px;box-shadow:none;background:#f0f7fb}
.feature-copy{padding:38px 42px;background:linear-gradient(110deg,#f8fbfd,#eef7fb)}
.feature-copy h2{font-size:43px;max-width:500px;margin-bottom:20px;line-height:1.08}
.feature-copy p{font-size:15px;line-height:1.65;max-width:440px}
.feature-art{background:linear-gradient(135deg,#f0f8fc,#e0eff6);border-left:0;padding:20px 30px}
.feature-art svg{max-height:285px}.art-legend{font-size:9px}
.section{padding-top:52px}.section-heading{margin-bottom:23px}.section-heading h2{font-size:33px}.section-heading p{font-size:14px}
.grid{gap:22px}.grid.four{gap:18px}
.card{border:1px solid #d6e6ef;border-radius:12px;box-shadow:0 3px 8px #163d5605}
.card:hover{box-shadow:0 7px 18px #163d5610}
.card-art{height:180px;background:linear-gradient(145deg,#f2f9fc,#e0eff7);padding:15px 28px 8px}.card-art svg{height:155px}
.card-body{padding:25px}.card h2,.card h3{font-size:26px;line-height:1.14;letter-spacing:-.035em}.card p{font-size:14px;line-height:1.7;color:#405b70}
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.foundation-card .card-body{padding:23px}.foundation-card h2,.foundation-card h3{font-size:24px}.foundation-card .mini-icon{width:43px;height:43px;border-radius:50%;margin-bottom:22px}
.topic-tile{padding:25px 23px;background:#edf6fa;border-radius:11px;min-height:84px}.topic-tile svg{width:28px}
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.breadcrumb{font-size:11px;margin:28px 0 25px;gap:12px}
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.metadata{gap:10px 19px;font-size:11px;max-width:850px;margin-top:24px;line-height:1.7}
.metadata .draft-dot{background:#fff3df;color:#6b4109;padding:4px 9px;border:1px solid #f0d3a4;border-radius:5px}
.opt-article-utilities{display:flex;gap:24px;align-items:center;margin-top:21px;font-size:12px}
.opt-evidence-link{font-weight:750;text-decoration:none;color:#075783}.opt-start-link{text-decoration:none;color:#385a73}
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.article-layout{max-width:1120px;grid-template-columns:minmax(0,760px) 270px;gap:60px;align-items:start;margin-top:36px}
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.contents h2{font-family:Georgia,serif;font-size:22px;letter-spacing:-.025em;text-transform:none;color:var(--ink);margin-bottom:17px}
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.contents li:before{content:counter(toc,decimal-leading-zero);font-size:9px;color:#50758e;padding-top:3px;font-weight:600}
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.contents .side-note{font-size:10px;padding-top:16px;line-height:1.7;border:0}
.contents .side-note a{font-size:10px}
.opt-rail-source{margin-top:17px;border:1px solid #a4c3d6;border-radius:7px;padding:11px 13px;background:#fff;font-weight:750}
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.answer-box p{font-size:18px;line-height:1.8;color:#16334c}
.article-section{margin-top:42px}.article-body>.article-section{padding-top:30px;border-top:1px solid #dce9f0;position:relative}
.article-body>.article-section:before{content:attr(data-section-number);font:700 10px var(--sans);letter-spacing:.12em;color:#0b527c;display:block;margin-bottom:13px}
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.article-section p{margin-bottom:22px}
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.concept-pills{margin:22px 0 34px;gap:8px}.pill{font-size:11px;padding:7px 12px;background:#f7fbfd}
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.sources{margin-top:46px;padding-top:32px;font-size:13px;color:#31516a}.sources h2{font-size:31px}.sources>p{font-size:13px;line-height:1.75}
.sources ol{list-style:none;counter-reset:source;padding:0;margin:26px 0}
.sources li{position:relative;counter-increment:source;border-top:1px solid #d9e8f1;padding:19px 16px 19px 47px;margin:0;background:#f8fbfd;font-size:13px}
.sources li:before{content:counter(source);position:absolute;left:15px;top:21px;color:#0b527c;font:700 11px var(--sans)}
.sources li>a{font-weight:650;line-height:1.6;color:#0b527c}.sources .source-type{font-size:11px;margin-top:6px}.sources .source-meta{font-size:10px;line-height:1.8;margin-top:5px}
.answer-box h2{font-size:29px;line-height:1.18;margin:8px 0 14px;color:#0b203c}.reading-levels{margin:30px 0 34px;padding:18px 20px;border:1px solid #cfe2ee;border-radius:10px;background:#f7fbfd}.reading-levels>div{display:flex;flex-wrap:wrap;gap:10px 24px;margin-top:10px}.reading-levels a{font-size:13px;font-weight:700;color:#0b527c;text-decoration:none}.reading-levels a:hover{text-decoration:underline}
.profile-summary,.reader-takeaway{margin:28px 0;padding:26px 28px;border:1px solid #cfe3ee;border-left:4px solid #e58336;border-radius:12px;background:#f5fafc}.profile-summary h2,.reader-takeaway h2{margin:5px 0 18px;font-size:28px}.profile-summary-item{padding:13px 0;border-top:1px solid #d9e8f1}.profile-summary-item h3{font:700 11px var(--sans);letter-spacing:.08em;text-transform:uppercase;color:#315872;margin-bottom:6px}.profile-summary-item p,.reader-takeaway p{margin:0;font-size:15px;line-height:1.7}.reader-takeaway p+p{margin-top:12px}
.further-reading ul{list-style:none;padding:0;margin:26px 0}.further-reading li{padding:19px 20px}.further-reading li:before{content:none}.further-reading li .source-meta,.further-reading li .small{display:block;margin-top:5px}.answer-box>.draft-dot{display:inline-block;background:#fff3df;color:#6b4109;padding:4px 9px;border:1px solid #f0d3a4;border-radius:5px;font-size:11px}
.page-tools{padding:23px 0}.bottom-related{padding-top:35px;margin-top:40px}.bottom-related .card-body{padding:21px}.bottom-related .card h2,.bottom-related .card h3{font-size:24px}
.page-intro{padding:52px 0 32px}.page-intro h1{font-size:60px;margin-bottom:22px}.page-intro .lede{font-size:19px;max-width:820px;line-height:1.65}
.info-layout{max-width:900px}.info-layout .article-section{font-size:17px;line-height:1.85}
.opt-topic-navigation{display:flex;gap:9px;flex-wrap:wrap;padding:0 0 28px}.opt-topic-navigation a{padding:8px 13px;background:#edf6fa;border:1px solid #d4e5ef;border-radius:7px;text-decoration:none;font-size:11px;color:#214e6b}
.filter-bar{background:#f4f9fc;border-radius:11px;padding:22px;box-shadow:none}.filter-bar select,.state-select select{min-height:42px;background:#fff;color:#1d405a;border:1px solid #adcadb;border-radius:7px}
.search-form{max-width:870px;gap:10px}.search-form input{border-color:#a6c3d6;background:#fff;border-radius:9px;font-size:17px;padding:16px 18px}.search-form .button{padding:12px 25px}
.search-result{padding:25px;border-radius:11px;box-shadow:none}.search-result h2,.search-result h3{font-size:27px}.search-result p{font-size:14px;line-height:1.75}
.alphabet{gap:6px;flex-wrap:wrap}.alphabet button{min-width:32px;min-height:36px;border-radius:6px;font-size:12px}
.term-row{padding:27px 0;border-color:#d5e6ef}.term-row h2{font-size:28px}.term-row p{line-height:1.8}
.path-step{padding:29px;background:#f7fbfd;border-radius:12px;box-shadow:none}.path-step h2{font-size:30px}.path-step p{line-height:1.8}
.form-card{border-radius:13px;background:#f7fbfd;padding:32px;box-shadow:none}.form-card input,.form-card textarea,.form-card select{background:#fff;border-color:#a9c5d6;border-radius:7px;min-height:44px}
.state-select{padding:22px;background:#f5fafd}.service-result{padding:30px;border-radius:12px;background:#edf6fb}.service-result h2{font-size:31px}
.stepper{border-radius:13px;background:#fff;box-shadow:0 4px 15px #1b526c08}.stepper-header{padding:20px 23px;background:#f4f9fc}.stepper .scene{padding:23px}.stepper .scene svg{background:#eaf5fb;height:280px;margin-bottom:26px}.scene h2,.scene h3{font-size:30px}.scene p{font-size:16px}.stepper-controls{padding:16px 23px}.step-indicators button{width:11px;height:11px}.step-indicators{gap:9px}
.dialog{width:min(660px,calc(100vw - 32px));border-radius:15px;box-shadow:0 24px 90px #08284640}.dialog::backdrop{background:#0a274559;backdrop-filter:blur(4px)}.dialog-head{background:#eff7fb;padding:20px 26px}.dialog-content{padding:31px}.dialog-content h2{font-size:35px;line-height:1.15}.dialog-content p{font-size:16px;line-height:1.8}
.review-table{font-size:12px}.review-table th{background:#eaf4fa;padding:18px 15px}.review-table td{padding:18px 15px}.review-table tr:nth-child(even){background:#f7fbfd}.review-summary{gap:18px}.review-stat{background:#edf6fb;box-shadow:none;padding:24px}.review-stat b{font-size:40px}
.site-footer{margin-top:75px;padding-top:46px;background:#eff6fa;border-top:1px solid #d4e5ee}.footer-grid{gap:40px}.footer-brand p{font-size:13px;line-height:1.8}.footer-col a{font-size:12px;line-height:1.7}.footer-bottom{font-size:10px;line-height:1.8}
@media(max-width:1100px){.container{padding-left:28px;padding-right:28px}.header-inner{gap:24px}.brand{font-size:27px}.desktop-nav{gap:19px}.header-actions [data-search-open]{min-width:190px}.home-opening h1{font-size:50px}.opt-home-copy{max-width:550px}.article-layout{grid-template-columns:minmax(0,1fr) 240px;gap:36px}.article-title h1{font-size:54px}.opt-metabolic-title h1{font-size:64px}}
@media(max-width:900px) and (min-width:761px){.opt-search-label{display:none}.header-actions [data-search-open]{min-width:44px;width:44px;padding:12px}.article-layout{grid-template-columns:minmax(0,1fr) 205px;gap:28px}.article-layout>.contents{padding:20px 16px}.contents h2{font-size:20px}.contents a{font-size:10px}}
@media(max-width:760px){
 .container{padding-left:20px;padding-right:20px}.header-inner{min-height:73px;gap:12px}.brand{font-size:26px;gap:9px}.brand-symbol{width:28px;height:28px;border-width:6px}.brand-symbol:after{top:3px;width:10px;height:10px}.header-actions [data-search-open]{min-width:38px;width:38px;height:38px;padding:9px;border-radius:50%}.opt-search-label{display:none}.desktop-nav{display:none}.header-actions{gap:7px}.icon-btn{width:38px;height:38px}
 .preview-strip .container{font-size:9px;min-height:30px}.home-opening{min-height:0;padding:30px 25px 105px;margin-top:20px;border-radius:15px;background-size:auto 100%;background-position:68% bottom;background-image:linear-gradient(180deg,#f1f8fc 0%,rgba(241,248,252,.99) 55%,rgba(241,248,252,.2) 100%),url('/assets/receptor-atmosphere.png')}.home-opening h1{font-size:39px;line-height:1.05;margin-bottom:18px}.home-opening .lede{font-size:15px;line-height:1.65;margin:0 0 22px;max-width:none}.opt-home-copy .eyebrow{font-size:9px;margin-bottom:15px}.opt-research-search{padding:5px;gap:2px}.opt-research-search input{font-size:12px;padding:9px 7px;min-width:0}.opt-research-search button{min-height:40px;font-size:11px;padding:8px 12px}.opt-drug-links{font-size:10px;gap:9px 11px;margin-top:15px}.opt-hero-caption{font-size:8px;right:18px;bottom:18px}
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 .home-feature{grid-template-columns:1fr;min-height:0}.feature-copy{padding:29px 25px}.feature-copy h2{font-size:34px}.feature-copy p{font-size:15px}.feature-art{padding:18px 22px;border-top:1px solid #d1e5ef}.feature-art svg{max-height:240px}.section{padding-top:39px}.section-heading{margin-bottom:19px;gap:12px}.section-heading h2{font-size:29px}.section-heading .link-arrow{font-size:10px}
 .grid,.grid.four,.grid.two{grid-template-columns:1fr;gap:17px}.card-body,.foundation-card .card-body{padding:23px}.card h2,.card h3,.foundation-card h2,.foundation-card h3{font-size:26px}.card p,.foundation-card p{font-size:14px}.card-art{height:175px}.card-art svg{height:150px}.foundation-card .mini-icon{margin-bottom:16px}.topic-tiles{gap:11px}.topic-tile{padding:19px 15px;font-size:12px;min-height:83px}.topic-tile svg{width:22px}.editorial-band{padding:25px}.editorial-band h2{font-size:28px}
 .breadcrumb{font-size:10px;margin:22px 0;flex-wrap:wrap;gap:7px}.article-title{padding:6px 0 26px}.article-title h1,.opt-metabolic-title h1{font-size:41px;line-height:1.06;margin-bottom:20px;max-width:100%;overflow-wrap:anywhere}.article-title .eyebrow{font-size:9px;margin-bottom:15px}.article-title .lede{font-size:17px;line-height:1.65;margin-bottom:20px}.opt-metabolic-title{background:none}.metadata{font-size:10px;gap:8px 14px;margin-top:20px}.metadata .draft-dot{padding:4px 7px}.opt-article-utilities{font-size:11px;margin-top:18px;gap:19px}
 .article-layout{display:block;margin-top:24px}.article-layout>.contents{display:none}.article-layout>.article-body{font-size:17px;line-height:1.85;width:100%;max-width:100%}.mobile-contents{background:#f6fafd;border:1px solid #c9dfec;border-radius:9px;padding:14px 16px;margin-bottom:23px;font-size:12px}.mobile-contents summary{font-weight:650}.mobile-contents a{padding:8px 0}
 .answer-box{padding:24px 23px;border-radius:4px 11px 11px 4px;margin-bottom:25px}.answer-box .eyebrow{font-size:24px;margin-bottom:14px}.answer-box p{font-size:16px;line-height:1.85}.article-section,.article-body>.article-section{margin-top:33px;padding-top:25px}.article-section h2{font-size:29px;line-height:1.2;margin-bottom:19px}.article-section p{margin-bottom:21px}.article-body>.article-section:before{margin-bottom:11px}.concept-pills{gap:7px;margin:22px 0}.pill{font-size:10px;padding:7px 10px}.concept-pills .label{font-size:10px}
 .figure-panel{margin:26px 0}.figure-panel figcaption{font-size:11px;padding:14px 16px}.study-facts{grid-template-columns:1fr;margin-top:23px;font-size:13px}.study-facts div{padding:17px 19px}.study-facts div:nth-child(odd){border-right:0}.study-note,.notice{font-size:12px;padding:19px}.status-card{padding:22px}.status-card p{font-size:13px}.sources{padding-top:28px;margin-top:36px}.sources h2{font-size:29px}.sources li{font-size:12px;padding:17px 12px 17px 38px;overflow-wrap:anywhere}.sources li:before{left:12px;top:20px}.sources .source-type{font-size:10px}.sources .source-meta{font-size:9px}
 .page-intro{padding:35px 0 24px}.page-intro h1{font-size:42px;line-height:1.07}.page-intro .lede{font-size:17px}.info-layout .article-section{font-size:17px}.opt-topic-navigation{gap:7px;padding-bottom:25px}.opt-topic-navigation a{font-size:10px;padding:7px 11px}.filter-bar{padding:17px}.filter-bar label{font-size:12px}.search-form{gap:8px}.search-form input{font-size:14px;padding:13px;min-width:0}.search-form .button{font-size:12px;padding:10px 17px}.search-result{padding:22px}.search-result h2{font-size:26px}.alphabet{gap:5px}.alphabet button{min-width:29px;min-height:33px;font-size:11px}.term-row{padding:23px 0}.term-row h2{font-size:27px}
 .path-step{padding:22px;gap:13px}.path-step h2{font-size:27px}.form-card{padding:24px}.state-select{padding:19px}.service-result{padding:25px}.service-result h2{font-size:28px}.stepper-header{padding:17px}.stepper .scene{padding:18px}.stepper .scene svg{height:200px;margin-bottom:23px}.scene h2,.scene h3{font-size:28px}.scene p{font-size:15px}.stepper-controls{padding:15px 13px}.stepper-controls .button{padding:7px 10px;font-size:11px}.step-indicators{gap:6px}.step-indicators button{width:9px;height:9px}.dialog-content{padding:25px}.dialog-content h2{font-size:30px}.dialog-content p{font-size:15px}.dialog-head{padding:17px 21px}.bottom-related .grid{grid-template-columns:1fr}.bottom-related .card-art{height:160px}.bottom-related .card-art svg{height:140px}.review-summary{gap:12px}.review-stat{padding:19px}.review-stat b{font-size:34px}.review-table th,.review-table td{padding:15px 12px}.site-footer{margin-top:48px;padding-top:36px}.footer-grid{gap:28px}.footer-col a{font-size:12px}
}
@media(prefers-reduced-motion:reduce){*{scroll-behavior:auto!important;transition:none!important}}

/* Homepage refinement from the complete H01 Before image, including lower sections. */
@media(min-width:1101px){
 .home-opening{min-height:0;padding:46px 44px 38px}
 .opt-home-copy{max-width:none}
 .home-opening h1{max-width:78%;font-size:58px;margin-bottom:30px}
 .home-opening .lede{position:absolute;right:0;top:120px;max-width:190px;font-size:14px}
 .opt-research-search{max-width:720px}
 .opt-hero-caption{display:none}
}
.opt-drug-links{display:grid;grid-template-columns:repeat(6,minmax(0,1fr));gap:10px;max-width:none;margin-top:23px}
.opt-drug-links>span{grid-column:1/-1;font-size:10px;letter-spacing:.05em}
.opt-drug-links a{display:flex;align-items:center;justify-content:center;min-height:55px;padding:12px 8px;border:1px solid #c3deed;border-radius:10px;background:rgba(255,255,255,.88);box-shadow:0 3px 8px #1c526a08;font-size:13px;line-height:1.3;text-align:center}
.opt-drug-links a:hover{background:#fff;border-color:#8ebdd6}
.opt-foundation-art{height:112px;background:radial-gradient(circle at 85% 110%,#d0e8f5 0,transparent 66%),linear-gradient(135deg,#f6fbfe,#e6f3fa);display:flex;align-items:center;justify-content:center;border-bottom:1px solid #d5e7f0}
.foundation-card .opt-foundation-art .mini-icon{width:62px;height:62px;margin:0;background:rgba(255,255,255,.82);border:1px solid #bdd9e9;border-radius:16px;box-shadow:0 6px 20px #17547c09}
.opt-foundation-art .mini-icon svg{width:38px;height:38px}
@media(max-width:1100px){.opt-drug-links{grid-template-columns:repeat(3,minmax(0,1fr))}.opt-drug-links a{min-height:45px;font-size:11px}}
@media(max-width:760px){.opt-drug-links{gap:8px;margin-top:19px}.opt-drug-links a{padding:10px 6px}.opt-foundation-art{height:120px}}
@media(min-width:1101px){.home-opening .lede{top:102px;max-width:210px;padding:14px;background:rgba(247,252,255,.93);border:1px solid #d3e6f1;border-radius:9px;font-size:13px;color:#16364e}}

.language-switcher{display:flex;align-items:center;gap:4px;font:700 11px var(--sans);white-space:nowrap}.language-switcher a{color:#245a7c;text-decoration:none;padding:7px 5px;border-radius:5px}.language-switcher a[aria-current="page"]{background:#e3f0f7;color:#083e60}.language-switcher a:focus-visible{outline:2px solid #e58336;outline-offset:2px}

.translation-notice{padding:7px 20px;text-align:center;background:#fff5e7;color:#694300;font:600 12px/1.45 var(--sans)}

@media(max-width:375px){
 .header-inner{display:grid;grid-template-columns:minmax(0,1fr) auto auto;gap:4px 7px;padding-top:8px;padding-bottom:8px}
 .header-inner .brand{grid-column:1/-1}
 .header-actions{display:contents}
 .header-actions .language-switcher{grid-column:1;grid-row:2}
 .header-actions [data-search-open]{grid-column:2;grid-row:2}
 .header-actions .mobile-menu-button{grid-column:3;grid-row:2}
}